Article
Endothelial nitric oxide synthase gene influences the risk of pre-eclampsia, the recurrence of negative pregnancy events, and the maternal-fetal flow.
Journal of hypertension - 1 Sept 2006
Fatini Cinzia, Sticchi Elena, Gensini Francesca, Genuardi Maurizio, Tondi Filippo, Gensini Gian Franco, Riviello Chiara, Parretti Elena, Mello Giorgio, Abbate Rosanna
Abstract excerpt
OBJECTIVES: Pre-eclampsia is associated with vascular endothelial dysfunction, adverse pregnancy outcome and cardiovascular disease in later life. An inadequate nitric oxide availability related to polymorphisms in the endothelial nitric oxide synthase gene (eNOS) might predispose to the disease. METHODS: We investigated the role of eNOS T-786C, G894T and 4a4b polymorphisms in predisposing to both pre-eclampsia...
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