Article
Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia.
Acta obstetricia et gynecologica Scandinavica - 1 Jan 2007
Benedetto Chiara, Marozio Luca, Ciccone Giovannino, Chieppa Giuseppina, Quaglia Marco, Matullo Giuseppe, Bertola Laura, Guarrera Simonetta, Carturan Sonia, Stratta Piero
Abstract excerpt
BACKGROUND: Components of the renin-angiotensin system and endothelial nitric oxide synthase may co-operate in spiral artery remodelling during placentation, and thus reduce the uteroplacental resistance typical of normal pregnancy. Since lack of such remodelling and abnormal placentation are specific features of pre-eclampsia, it has been suggested that abnormal function of both components of the...
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