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Article

Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditions.

Experimental gerontology - 1 Sept 2006

Golubovsky Mikhail D, Weisman Nataly Y, Arbeev Konstantin G, Ukraintseva Svetlana V, Yashin Anatoly I

Abstract excerpt

Recent studies suggest that downregulation of tumor suppressor genes might not only favor cancer development but also postpone organisms' aging and increase longevity. However, there is lack of population-based studies directly supporting this idea. We studied the lgl lethal alleles which are widespread in natural Drosophila populations. We demonstrate, for the first time, that animals heterozygous on the...

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Identifiers

PMID: 16905287
DOI: 10.1016/j.exger.2006.06.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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