Article
No evidence for maternal-fetal microchimerism in infantile hemangioma: a molecular genetic investigation.
The Journal of investigative dermatology - 1 Nov 2006
Pittman Kristianna M, Losken H Wolfgang, Kleinman Mark E, Marcus Jeffrey R, Blei Francine, Gurtner Geoffrey C, Marchuk Douglas A
Abstract excerpt
In this study, using the placental origin theory as a basis, we set out to explore whether hemangioma endothelial cells (HEC) were maternal in origin. We rigorously addressed this hypothesis using several molecular genetic techniques. Fluorescent in situ hybridization on surgical specimens of proliferating hemangiomas (n=8) demonstrated no XX-labeled HEC from resected tumors of male infants. This analysis was...
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