Monoclonal expansion of endothelial cells in hemangioma: an intrinsic defect with extrinsic consequences?

Abstract excerpt

Infantile hemangioma is a benign tumor of endothelial cells (ECs) that is well known to pediatricians because of its frequency and sometimes disturbingly rapid growth. The primary defect(s) that cause hemangioma have not yet been elucidated, but recent studies have revealed that hemangiomas are composed of clonal ECs that exhibit abnormal properties in vitro. These studies support the hypothesis that hemangiomas...

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