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Article

Relationship of hepatic functional imaging to irinotecan pharmacokinetics and genetic parameters of drug elimination.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2006

Michael Michael, Thompson Mick, Hicks Rod J, Mitchell Paul L, Ellis Andrew, Milner Alvin D, Di Iulio Julia, Scott Andrew M, Gurtler Volker, Hoskins Janelle M, Clarke Stephen J, Tebbut Niall C, Foo Kian, Jefford Michael, Zalcberg John R

Abstract excerpt

PURPOSE: The marked variability of irinotecan (Ir) clearance warrants individualized dosing based on hepatic drug handling. The aims of this trial were to identify parameters from functional hepatic nuclear imaging (HNI) that correlate with (1) Ir pharmacology, and (2) single-nucleotide polymorph...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16896007
DOI: 10.1200/JCO.2005.04.8496

Genes

ABCB1
RET
ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16896007-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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