Article
Proteomic analysis of a penicillin-tolerant rgg mutant strain of Streptococcus pyogenes.
The Journal of antimicrobial chemotherapy - 1 Oct 2006
Chaussee Michelle A, McDowell Emily J, Rieck Lindsey D, Callegari Eduardo A, Chaussee Michael S
Abstract excerpt
OBJECTIVES: To determine whether the transcriptional regulator Rgg contributes to penicillin-induced killing of Streptococcus pyogenes by altering a regulatory response to penicillin. METHODS: Penicillin-induced killing of a wild-type and isogenic rgg mutant strain was assessed in broth and solid media and in the presence of cerulenin, which inhibits fatty acid biosynthesis (FAB). Proteins from wild-type and rgg...
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