Article
Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease.
Journal of vascular surgery - 1 Aug 2006
Vainas Tryfon, Stassen Frank R M, Bruggeman Cathrien A, Welten Rob J Th J, van den Akker Luc H J M, Kitslaar Peter J E H M, Peña Amado S, Morré Servaas A
Abstract excerpt
BACKGROUND: Genes involved in the regulation of immune responses, such as Toll-like receptor 4 (TLR4) and CD14, show genetic variations with potential functional implications. Because atherosclerosis is an inflammatory process apparently modulated by chronic infections, we studied the effect of s...
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