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Article

Trisomy 21 Causes Persistent Congenital Hypothyroidism Presumably of Thyroidal Origin

1 Jul 2006

Abstract excerpt

OBJECTIVE AND DESIGN: Lowered neonatal plasma thyroxine (T(4)) and mildly elevated thyrotropin concentrations together with developmental benefits from neonatally started T(4) treatment in a randomized clinical trial demonstrated Down syndrome (DS) neonates to be mildly hypothyroid, at least during their first weeks of life. To prove that this hypothyroid state persists beyond this period in all, and to elucidate...

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PMID: 16889491
DOI: 10.1089/thy.2006.16.671

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