Article
Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea.
Stem cells (Dayton, Ohio) - 1 Dec 2006
Yoshida Satoru, Shimmura Shigeto, Nagoshi Narihito, Fukuda Keiichi, Matsuzaki Yumi, Okano Hideyuki, Tsubota Kazuo
Abstract excerpt
We report the presence of neural crest-derived corneal precursors (COPs) that initiate spheres by clonal expansion from a single cell. COPs expressed the stem cell markers nestin, Notch1, Musashi-1, and ABCG2 and showed the side population cell phenotype. COPs were multipotent with the ability to differentiate into adipocytes, chondrocytes, as well as neural cells, as shown by the expression of beta-III-tubulin,...
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