Article
Possible correlation between polymorphism in the tumor necrosis factor-beta gene and the clinicopathological features of bladder cancer in Japanese patients.
International journal of urology : official journal of the Japanese Urological Association - 1 Jul 2006
Nonomura Norio, Tokizane Takashi, Nakayama Masashi, Inoue Hitoshi, Nishimura Kazuo, Muramatsu Masaaki, Okuyama Akihiko
Abstract excerpt
OBJECTIVES: In a variety of cancers, several polymorphisms of the tumor necrosis factor (TNF) genes have been reported to result in different clinical outcomes. We investigated whether a polymorphism of the TNF gene is associated with a susceptibility to bladder cancer and its disease status. METHODS: Polymorphisms in the TNF-alpha gene promoter (-308 bp) and the NcoI site in the first intron of the TNF-beta gene...
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