Article
Evidence for multiple loci from a genome scan of autism kindreds.
Molecular psychiatry - 1 Nov 2006
Schellenberg G D, Dawson G, Sung Y J, Estes A, Munson J, Rosenthal E, Rothstein J, Flodman P, Smith M, Coon H, Leong L, Yu C-E, Stodgell C, Rodier P M, Spence M A, Minshew N, McMahon W M, Wijsman E M
Abstract excerpt
We performed a genome-wide linkage scan using highly polymorphic microsatellite markers. To minimize genetic heterogeneity, we focused on sibpairs meeting the strict diagnosis of autism. In our primary analyses, we observed a strong linkage signal (P=0.0006, 133.16 cM) on chromosome 7q at a location coincident with other linkage studies. When a more relaxed diagnostic criteria was used, linkage evidence at this...
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