Article
Solution for underflow problem in linkage and segregation analysis.
Computational biology and chemistry - 1 Oct 2006
Axenovich Tatiana I, Aulchenko Yurii S
Abstract excerpt
Finding genes for complex traits is one of the major challenges of modern human genetics. Current developments of molecular techniques facilitated use of large pedigrees and marker sets of thousands of single-nucleotide polymorphisms (SNPs). However, one of the problems occurring in statistical analysis of such large data sets is that the likelihood is very low and underflow may easily occur. In this work we...
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