Article
Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge.
Antimicrobial agents and chemotherapy - 1 Aug 2006
Steffen H, Rieg S, Wiedemann I, Kalbacher H, Deeg M, Sahl H-G, Peschel A, Götz F, Garbe C, Schittek B
Abstract excerpt
Dermcidin (DCD) is a recently described antimicrobial peptide, which is constitutively expressed in eccrine sweat glands and transported via sweat to the epidermal surface. By postsecretory proteolytic processing in sweat the dermcidin protein gives rise to several truncated DCD peptides which differ in length and net charge. In order to understand the mechanism of antimicrobial activity, we analyzed the spectrum...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.