Article
Peptide Self-Assembly Is Linked to Antibacterial, but Not Antifungal, Activity of Histatin 5 Derivatives.
mSphere - 1 Apr 2020
Schnaider Lee, Rosenberg Alexander, Kreiser Topaz, Kolusheva Sofiya, Gazit Ehud, Berman Judith
Abstract excerpt
The rise of multidrug-resistant pathogens has awakened interest in new drug candidates such as antimicrobial peptides and their derivatives. Recent work suggests that some antimicrobial peptides have the ability to self-assemble into ordered amyloid-like nanostructures which facilitate their antibacterial activity. Here, we evaluate a histatin-based antimicrobial peptide, and its self-assembling derivative, in...
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