Article
An in vitro model to study chemoresistance in non-Hodgkin's lymphoma patients over-expressing mutant p53.
Journal of pharmacological and toxicological methods - 1 Jan 2000
Foroutan Behzad, Ruf Afruj Ali, Costall Brenda, Anderson Diana
Abstract excerpt
INTRODUCTION: P-Glycoprotein plays a major role in regulating the concentration of chemotherapeutic agents inside the cytoplasm of normal and cancerous cells. The present in vitro study has primarily focused on the evaluation of the chemosensitising drug model, verapamil, as a P-glycoprotein antagonist not only to overcome chemoresistance in non-Hodgkin's lymphoma (NHL) chemoresistant cells (p53(+) i.e....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
