Article
Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2006
Hsieh Meng-Heng, Fang Yueh-Fu, Chang Wen-Cheng, Kuo Han-Pin, Lin Shinn-Yn, Liu Hui-Ping, Liu Chih-Lin, Chen Hsiu-Chi, Ku Yuan-Chieh, Chen Ya-Ting, Chang Ya-Hui, Chen Ying-Tsong, Hsi Bae-Li, Tsai Shih-Feng, Huang Shiu-Feng
Abstract excerpt
Mutational analysis was performed in the kinase domain (exons 18-21) of the EGFR gene on tumor tissues of 65 non-small cell lung cancer (NSCLC) patients who had received gefitinib monotherapy. The association between EGFR gene mutation, gefitinib treatment response, and the overall survival were...
Topics
- Adenocarcinoma
- Antineoplastic Agents
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- DNA Mutational Analysis
- DNA Primers
- ErbB Receptors
- Female
- Gefitinib
- Gene Expression Regulation, Neoplastic
- Humans
- In Situ Hybridization