Article
Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2006
Hsieh Meng-Heng, Fang Yueh-Fu, Chang Wen-Cheng, Kuo Han-Pin, Lin Shinn-Yn, Liu Hui-Ping, Liu Chih-Lin, Chen Hsiu-Chi, Ku Yuan-Chieh, Chen Ya-Ting, Chang Ya-Hui, Chen Ying-Tsong, Hsi Bae-Li, Tsai Shih-Feng, Huang Shiu-Feng
Abstract excerpt
Mutational analysis was performed in the kinase domain (exons 18-21) of the EGFR gene on tumor tissues of 65 non-small cell lung cancer (NSCLC) patients who had received gefitinib monotherapy. The association between EGFR gene mutation, gefitinib treatment response, and the overall survival were evaluated. In total, EGFR mutations with complex patterns were identified in 32 tumors. The overall mutation rate was...
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