Article
Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2006
Bellizzi Dina, Cavalcante Paola, Taverna Daniela, Rose Giuseppina, Passarino Giuseppe, Salvioli Stefano, Franceschi Claudio, De Benedictis Giovanna
Abstract excerpt
Some lines of evidence indicate that common polymorphisms of mitochondrial DNA (mtDNA) act as susceptibility factors in complex traits, such as age-related common diseases. There is also evidence that the cell capability to compensate ravages caused by intrinsic or extrinsic stress factors could contribute to some of these diseases. The cross-talk between nuclear and mitochondrial genome may link the above...
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