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Article

The pseudo-mitochondrial genome influences mistakes in heteroplasmy interpretation.

BMC genomics - 21 Jul 2006

Parr Ryan L, Maki Jennifer, Reguly Brian, Dakubo Gabriel D, Aguirre Andrea, Wittock Roy, Robinson Kerry, Jakupciak John P, Thayer Robert E

Abstract excerpt

BACKGROUND: Nuclear mitochondrial pseudogenes (numts) are a potential source of contamination during mitochondrial DNA PCR amplification. This possibility warrants careful experimental design and cautious interpretation of heteroplasmic results. RESULTS: Here we report the cloning and sequencing of numts loci, amplified from human tissue and rho-zero (rho0) cells (control) with primers known to amplify the...

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Identifiers

PMID: 16859552
DOI: 10.1186/1471-2164-7-185
PMCID: PMC1538596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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