Article
Using secondary structure to identify ribosomal numts: cautionary examples from the human genome.
Molecular biology and evolution - 1 Jan 2002
Olson Link E, Yoder Anne D
Abstract excerpt
The identification of inadvertently sequenced mitochondrial pseudogenes (numts) is critical to any study employing mitochondrial DNA sequence data. Failure to discriminate numts correctly can confound phylogenetic reconstruction and studies of molecular evolution. This is especially problematic for ribosomal mtDNA genes. Unlike protein-coding loci, whose pseudogenes tend to accumulate diagnostic frameshift or...
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