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Article

Tryptophan hydroxylase 1 gene haplotypes modify the effect of a hostile childhood environment on adulthood harm avoidance.

Genes, brain, and behavior - 1 Jun 2007

Keltikangas-Järvinen L, Puttonen Sampsa, Kivimäki Mika, Elovainio Marko, Rontu Riikka, Lehtimäki Terho

Abstract excerpt

We conducted a series of tests to determine whether there is any association between tryptophan hydroxylase 1 (TPH1) and temperament in adulthood. In addition to testing for main effects, we investigated whether TPH1 gene variation modifies the influence of childhood environment on temperament in adulthood. The subjects were 341 healthy adults whose childhood environment was assessed by their mothers in 1980 and...

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Identifiers

PMID: 16848783
DOI: 10.1111/j.1601-183X.2006.00255.x

Genes

TPH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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