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Article

Inhibition of SUMO-independent PML oligomerization by the human cytomegalovirus IE1 protein

17 Jul 2006

Abstract excerpt

In human cytomegalovirus-infected cells, the immediate-early IE1 protein disrupts the subnuclear structures known as the PML oncogenic domains or PODs, via the induction of PML desumoylation. This activity correlates with the functions of IE1 in transcriptional regulation and in the stimulation of lytic infection. Here, the effects of IE1 in induction of desumoylation of PML were characterized. IE1 did not...

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PMID: 16847114
DOI: 10.1099/vir.0.81787-0

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