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Article

High-density genetic and physical mapping of DNA markers near the X-linked Alport syndrome locus: definition and use of flanking polymorphic markers.

Human genetics - 1 Dec 1991

Barker D F, Fain P R, Goldgar D E, Dietz-Band J N, Turco A E, Kashtan C E, Gregory M C, Tryggvason K, Skolnick M H, Atkin C L

Abstract excerpt

To refine the genetic and physical mapping of the locus for Alport syndrome (ATS), 22 X-chromosome restriction fragment length polymorphism (RFLP) markers that fall between Xq21.3 and Xq25 were tested for genetic linkage with the disease and also mapped with respect to a series of physical breakp...

Topics

Blotting, Southern
Collagen
Endodeoxyribonucleases
Female
Genetic Linkage
Humans
Hybrid Cells
Male
Mutation
Nephritis, Hereditary
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

X Chromosome

Source

Identifiers

PMID: 1684566
DOI: 10.1007/BF00206070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1684566-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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