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Article

High-density genetic and physical mapping of DNA markers near the X-linked Alport syndrome locus: definition and use of flanking polymorphic markers.

Human genetics - 1 Dec 1991

Barker D F, Fain P R, Goldgar D E, Dietz-Band J N, Turco A E, Kashtan C E, Gregory M C, Tryggvason K, Skolnick M H, Atkin C L

Abstract excerpt

To refine the genetic and physical mapping of the locus for Alport syndrome (ATS), 22 X-chromosome restriction fragment length polymorphism (RFLP) markers that fall between Xq21.3 and Xq25 were tested for genetic linkage with the disease and also mapped with respect to a series of physical breakpoints in this region. The location of the COL4A5 gene, which has recently been shown to be mutated in at least some...

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PMID: 1684566
DOI: 10.1007/BF00206070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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