Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a basic transthyretin variant--TTR Arg 102--in the German population.

Biochimica et biophysica acta - 21 Oct 1991

Almeida M R, Altland K, Rauh S, Gawinowicz M, Moreira P, Costa P P, Saraiva M J

Abstract excerpt

A basic transthyretin (TTR) variant, apparently non-pathogenic, has been reported in a German family. Protein analysis of this TTR variant revealed the substitution of arginine for proline at position 102 of the TTR polypeptide chain. This result was confirmed by DNA analysis of PCR amplified DNA.

Topics

Amyloidosis
Arginine
Base Sequence
Exons
Female
Genetic Testing
Genetic Variation
Germany
Humans
Molecular Sequence Data
Mutation
Peptide Mapping
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Prealbumin

Pregnancy

Proline

Source

Identifiers

PMID: 1681909
DOI: 10.1016/0925-4439(91)90039-c

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1681909-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Characterization of a basic transthyretin variant--TTR Arg 102--in the German population.PMID 1681909Read ↗

A new transthyretin variant--ATTR Arg104Cys.Semantic proximity Read ↗

Molecular analyses of an acidic transthyretin Asn 90 variant.Semantic proximity Read ↗

Identification of a new thyroglobulin variant: a guanine-to-adenine transition resulting in the substitution of arginine 2510 by glutamine.Semantic proximity Read ↗

Screening and biochemical characterization of transthyretin variants in the Portuguese population.Semantic proximity Read ↗

A specific test for transthyretin 122 (Val----Ile), based on PCR-primer-introduced restriction analysis (PCR-PIRA): confirmation of the gene frequency in blacks.Semantic proximity Read ↗

Revised transthyretin Ile 122 allele frequency in African-Americans.Semantic proximity Read ↗

An Israeli family with Gerstmann-Sträussler-Scheinker disease manifesting the codon 102 mutation in the prion protein gene.Semantic proximity Read ↗

Frequency and genetic background of the position 122 (Val----Ile) variant transthyretin gene in the black population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.