Article
A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals.
International journal of biological sciences - 1 Jan 2006
Xiao Qianjun, Wu Xiao-Lin, Michal Jennifer J, Reeves Jerry J, Busboom Jan R, Thorgaard Gary H, Jiang Zhihua
Abstract excerpt
People with obesity, especially extreme obesity, are at risk for many health problems. However, the responsible genes remain unknown in >95% of severe obesity cases. Our previous genome-wide scan of Wagyu x Limousin F2 cattle crosses with extreme phenotypes revealed a molecular marker significantly associated with intramuscular fat deposition. Characterization of this marker showed that it is orthologous to the...
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