Article
Structure and expression of the beta-platelet-derived growth factor receptor gene in human tumor cell lines.
Cancer research - 15 Oct 1991
Malik R, Gope M, Womer R B, Nagashunmugam T, Margolin J F, Basu A, Scher C D
Abstract excerpt
Southern digests of DNA from 15 human connective tissue tumor-derived cell lines (and cell strains) and from peripheral blood lymphocytes from normal volunteers were prepared to compare structure of the beta-platelet-derived growth factor receptor gene in normal and tumor-derived cells. The tumor-derived samples had no alterations in gene structure, nor was gene amplification evident. Two restriction fragment...
Topics
- Alleles
- Blotting, Northern
- Gene Expression Regulation, Neoplastic
- Glioma
- Humans
- Polymorphism, Restriction Fragment Length
- RNA, Messenger
- Receptors, Cell Surface
- Receptors, Platelet-Derived Growth Factor
- Sarcoma