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Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities.

Microbiology (Reading, England) - 1 Jul 2006

Coulthurst Sarah J, Williamson Neil R, Harris Abigail K P, Spring David R, Salmond George P C

Abstract excerpt

Serratia marcescens is an important cause of opportunistic human infections. Many, but not all, strains produce prodigiosin, a secondary metabolic, red-pigment antibiotic, the biosynthesis of which is directed by the pig gene cluster. Quorum sensing (QS) involves the production and detection of chemical signal molecules as a means to regulate gene expression in response to population cell density. Several strains...

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PMID: 16804166
DOI: 10.1099/mic.0.28803-0

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Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities.PMID 16804166Read ↗

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