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Article

The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate.

BMC microbiology - 28 May 2009

Gristwood Tamzin, Fineran Peter C, Everson Lee, Williamson Neil R, Salmond George P

Abstract excerpt

BACKGROUND: Secondary metabolism in Serratia sp. ATCC 39006 (Serratia 39006) is controlled via a complex network of regulators, including a LuxIR-type (SmaIR) quorum sensing (QS) system. Here we investigate the molecular mechanism by which phosphate limitation controls biosynthesis of two antibiotic secondary metabolites, prodigiosin and carbapenem, in Serratia 39006. RESULTS: We demonstrate that a mutation in...

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Identifiers

PMID: 19476633
DOI: 10.1186/1471-2180-9-112
PMCID: PMC2695467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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