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Article

Reduced binding of FGF1 to mutant fibroblast growth factor receptor 3.

Growth factors (Chur, Switzerland) - 1 Jun 2006

Khnykin Denis, Olsnes Sjur

Abstract excerpt

The activating mutation FGFR3-R248C in the D2-D3 linker region of fibroblast growth factor receptor 3 leads as germline mutation to the neonatal lethal syndrome thanatophoric dysplasia type I (TD1). As somatic mutation it has been found in cancer. We introduced into the murine FGFR3 the mutation R242C that is orthologoues to the human mutation R248C. A strong reduction in binding of the 16 and 18 kDa forms of...

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Source

Identifiers

PMID: 16801131
DOI: 10.1080/08977190600621388

Genes

FGFR3
FGF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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