Article
IL-8 (-251 A/T) and CXCR2 (+1208 C/T) gene polymorphisms and risk of multiple sclerosis in Iranian patients.
Neuroscience letters - 14 Aug 2006
Kamali-Sarvestani Eskandar, Nikseresht Ali-Reza, Aliparasti Mohammad-Reza, Vessal Mahmood
Abstract excerpt
IL-8 plays important roles in CNS development, modulation of neuronal survival and excitability. Among IL-8 receptors, only CXCR2 is known to be present in the brain. The ability of individuals in producing IL-8 is partially determined by IL-8 -251 A/T polymorphism. Therefore, the aim of the pres...
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