Article
Multihormonal resistance to parathyroid hormone, thyroid stimulating hormone, and other hormonal and neurosensory stimuli in patients with pseudohypoparathyroidism.
Journal of pediatric endocrinology & metabolism : JPEM - 1 May 2006
Wémeau Jean-Louis, Balavoine Anne-Sophie, Ladsous Miriam, Velayoudom-Cephise Fritz-Line, Vlaeminck-Guillem Virginie
Abstract excerpt
In patients with pseudohypoparathyroidism, hormonal resistance first affects parathyroid hormone (PTH), which leads to calcipenia, a decrease in renal vitamin D activation, and a tendency to bone receptor remodeling. However, because G proteins are ubiquitously distributed, multiple hormonal resistance occurs in pseudohypoparathyroidism type Ia and type Ic, impairing responses to other calciotropic hormones...
Topics
- Hearing
- Hormones
- Humans
- Parathyroid Hormone
- Parathyroid Hormone-Related Protein
- Phenotype
- Pseudohypoparathyroidism
- Receptors, Calcium-Sensing
- Sensory Thresholds
- Smell
- Taste
- Thyrotropin
- Vision, Ocular