Article
Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS).
Pharmacogenetics and genomics - 1 Jul 2006
Morón Francisco J, de Castro Francisco, Royo Jose L, Montoro Luis, Mira Emilia, Sáez María E, Real Luis M, González Alejandro, Mañes Santos, Ruiz Agustín
Abstract excerpt
OBJECTIVE: Controlled ovarian stimulation (COS) using recombinant follicle-stimulating hormone (rFSH) is the main treatment in assisted reproduction. We performed a pharmacogenetic analysis of bone morphogenetic protein 15 (BMP15) gene using single nucleotide polymorphisms (SNPs) in COS. We also investigated the role of the BMP15 gene in ovarian hyperstimulation syndrome (OHSS). METHODS: We analysed different...
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