Non classical HLA genes and non-HLA genes in a population of infants at familial risk of atopy.

doi:10.1155/2006/321798

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Article

Non classical HLA genes and non-HLA genes in a population of infants at familial risk of atopy.

Disease markers - 1 Jan 2006

De Silvestri A, Belloni C, De Amici M, Mazzola P, Zorzetto M, Martinetti M, Salvaneschi L, Cuccia M

Abstract excerpt

AIM: We investigated on parental history and IgE serum level in 2588 consecutive newborns to individuate babies "at risk" of atopy at birth and we analysed the polymorphisms of class III region to evaluate the association with immunogenetic markers of HLA: C4A, C4B, LTA, RAGE and TNFA genes; we performed TNF and IgE receptor (FCERB1) physiologically related gene polymorphisms. RESULT: 791 babies/2588 (30.6%) were...

Topics

Female
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Infant, Newborn
Male
Pedigree
Polymorphism, Genetic
Receptors, IgE
Receptors, Tumor Necrosis Factor

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PMID: 16788244
DOI: 10.1155/2006/321798
PMCID: PMC3851371

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