Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow <i>in vivo</i> according to their ability to inhibit CXCL12 binding to CXCR4 <i>in vitro</i>

Abstract excerpt

The CXCR4 antagonist, AMD3100, stimulates a rapid increase in circulating numbers of haematopoeitic progenitor cells (HPCs) in both mice and human healthy volunteers. An in situ perfusion system of the mouse femoral bone marrow was used to provide the first direct evidence that AMD3100 mobilises HPCs from the bone marrow. Structural analogues of AMD3100 demonstrated that the ability of these compounds to mobilise...

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