Article
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies.
Molecular cancer - 19 Jun 2006
Mattie Michael D, Benz Christopher C, Bowers Jessica, Sensinger Kelly, Wong Linda, Scott Gary K, Fedele Vita, Ginzinger David, Getts Robert, Haqq Chris
Abstract excerpt
BACKGROUND: Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a promising new class of cancer biomarkers. However, previously reported methods for measuring miRNA expression consume large amounts of tissue, prohibiting high-throughput miRNA profiling from typically small clinical samples such as excision or...
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