Article
Immunohistochemical expression of mismatch repair genes: a screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma.
World journal of gastroenterology - 21 Jun 2006
Liengswangwong Upama, Karalak Anant, Morishita Yukio, Noguchi Masayuki, Khuhaprema Thiravud, Srivatanakul Petcharin, Miwa Masanao
Abstract excerpt
AIM: To clarify possible contributions of DNA mismatch repair (MMR) system in carcinogenesis of liver fluke infection-associated intrahepatic cholangiocarcinoma (ICC) by using immunohistochemical assay. METHODS: A total of 29 ICC samples, which had been assessed for genomic instability by a PCR-based method, were used for study. They were examined immunohistochemically to demonstrate protein expression of two MMR...
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