Article
RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia.
Molecular psychiatry - 1 Jul 2001
Sodhi M S, Burnet P W, Makoff A J, Kerwin R W, Harrison P J
Abstract excerpt
5-HT(2C) receptor (5HT(2C)R, serotonin-2C) RNA undergoes editing to produce several receptor variants, some with pharmacological differences. This investigation comprised two parts: the characterisation of 5-HT(2C)R RNA editing in a larger human control sample than previously examined, and a comparative study in subjects with schizophrenia. Secondary structure analysis of the putative edited region of the human...
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