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Article

High proportion of novel mutations of BRCA1 and BRCA2 in breast/ovarian cancer patients from Castilla-León (central Spain).

Journal of human genetics - 1 Jan 2006

Infante Mar, Durán Mercedes, Esteban-Cardeñosa Eva, Miner Cristina, Velasco Eladio

Abstract excerpt

A total of 264 unrelated breast/ovarian cancer patients and 45 healthy individuals with familial antecedents referred for genetic testing were scanned for germ-line mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis (CSGE) and heteroduplex analysis by capillary array electrophoresis (HA-CAE). We detected 101 distinct mutations (41 in BRCA1 and 60 in BRCA2); ten of them have not been...

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Identifiers

PMID: 16758124
DOI: 10.1007/s10038-006-0404-7

Genes

BRCA2
BRCA1

Variants

Provenance

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