Article
Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism.
Biochemistry - 6 Jun 2006
Golovko Mikhail Y, Rosenberger Thad A, Faergeman Nils J, Feddersen Søren, Cole Nelson B, Pribill Ingrid, Berger Johannes, Nussbaum Robert L, Murphy Eric J
Abstract excerpt
Because alpha-synuclein (Snca) has a role in brain lipid metabolism, we determined the impact that the loss of alpha-synuclein had on brain arachidonic acid (20:4n-6) metabolism in vivo using Snca-/- mice. We measured [1-(14)C]20:4n-6 incorporation and turnover kinetics in brain phospholipids using an established steady-state kinetic model. Liver was used as a negative control, and no changes were observed...
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