Article
Sex hormones and SLE: influencing the fate of autoreactive B cells.
Current topics in microbiology and immunology - 1 Jan 2006
Cohen-Solal J F G, Jeganathan V, Grimaldi C M, Peeva E, Diamond B
Abstract excerpt
The prevalence of systemic lupus erythematosus (SLE) is far higher in females than in males and numerous investigations to understand this gender bias have been conducted. While it is plausible that some sex-linked genes may contribute to the genetic predisposition for the disease, other likely culprits are the sex hormones estrogen and prolactin. In this chapter we review studies that have addressed the...
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