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Identification of a novel amplicon at distal 17q containing the <i>BIRC5/SURVIVIN</i> gene in malignant peripheral nerve sheath tumours

23 May 2006

Abstract excerpt

Previous studies have suggested that amplification of genes, notably the TOP2A gene, on chromosome arm 17q may be important for the development of malignant peripheral nerve sheath tumour (MPNST). In order to study the frequency, distribution, and chromosomal organization of rearrangements at 17q, interphase and metaphase fluorescence in situ hybridization (FISH) were used to evaluate copy number changes at 17q...

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PMID: 16721726
DOI: 10.1002/path.1998

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