Article
Interleukin 6 G-174 C polymorphism and breast cancer risk.
European journal of epidemiology - 1 Jan 2006
González-Zuloeta Ladd A M, Arias Vásquez A, Witteman J, Uitterlinden A G, Coebergh J W, Hofman A, Stricker B H Ch, van Duijn C M
Abstract excerpt
Interleukin-6 (IL-6) is a growth factor involved in many processes including carcinogenesis. The C allele of the G-174 C promoter single nucleotide polymorphism (SNP) in the IL-6 gene decreases levels of IL-6 expression and it has been studied in the context of breast cancer progression yielding contradicting results. Furthermore a recent study found that carriers of the C allele were at an increased risk for...
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