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Article

VPg of murine norovirus binds translation initiation factors in infected cells

23 May 2006

Abstract excerpt

BACKGROUND: Norovirus genomic and subgenomic RNAs are covalently linked at the 5' nucleotide to a 15 kD protein called VPg. VPg of two human norovirus strains binds translation initiation factor eIF3 and other eIFs in vitro, suggesting VPg functions in initiation of protein synthesis on viral RNA. Human norovirus strains are not cultivable, and thus experimental evidence of interactions between VPg and eIFs in...

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PMID: 16719923
DOI: 10.1186/1743-422x-3-33

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