Article
De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study.
The Lancet. Neurology - 1 Jun 2006
Berkovic Samuel F, Harkin Louise, McMahon Jacinta M, Pelekanos James T, Zuberi Sameer M, Wirrell Elaine C, Gill Deepak S, Iona Xenia, Mulley John C, Scheffer Ingrid E
Abstract excerpt
BACKGROUND: Vaccination, particularly for pertussis, has been implicated as a direct cause of an encephalopathy with refractory seizures and intellectual impairment. We postulated that cases of so-called vaccine encephalopathy could have mutations in the neuronal sodium channel alpha1 subunit gene (SCN1A) because of a clinical resemblance to severe myoclonic epilepsy of infancy (SMEI) for which such mutations...
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