Article
Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2006
Kajihara Takeshi, Jones Marius, Fusi Luca, Takano Masashi, Feroze-Zaidi Fakhera, Pirianov Grisha, Mehmet Huseyin, Ishihara Osamu, Higham Jenny M, Lam Eric W-F, Brosens Jan J
Abstract excerpt
The integrity of the feto-maternal interface is critical for survival of the conceptus. This interface, consisting of the maternal decidua and the invading placental trophoblast, is exposed to profound changes in oxygen tension during pregnancy. We demonstrate that human endometrial stromal cells become extraordinarily resistant to oxidative stress-induced apoptosis upon decidualization in response to cAMP and...
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