Article
The program for phenotyping of genetically modified animals at AstraZeneca.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Jul 2006
Berg Anna-Lena, Bohlooly-Y Mohammad
Abstract excerpt
Genetically modified mice offer a wide range of possibilities in preclinical drug discovery, e.g. for use in target identification, target validation and disease model generation. However, genomic modification and alteration in gene expression may cause unpredicted phenotypic alterations in the o...
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