Extrarenal rhabdoid tumors of soft tissue: clinicopathological and molecular genetic review and distinction from other soft-tissue sarcomas with rhabdoid features.

Abstract excerpt

Malignant rhabdoid tumor (MRT) of the soft tissue is a rare and highly aggressive tumor that occurs in infancy or childhood. It predominantly involves a deep axial location such as the neck or paraspinal region. Microscopically, the tumor is composed of a diffuse proliferation of rounded or polygonal cells with eccentric nuclei, prominent nucleoli and glassy eosinophilic cytoplasm containing hyaline-like...

Topics

• Biomarkers, Tumor
• Child
• Child, Preschool
• Chromosomal Proteins, Non-Histone
• Cytogenetics
• DNA-Binding Proteins
• Diagnosis, Differential
• Humans
• Infant
• Molecular Biology
• Mutation