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Article

Nuclear Localization of Flavivirus RNA Synthesis in Infected Cells

12 May 2006

Abstract excerpt

Flaviviral replication is believed to be exclusively cytoplasmic, occurring within virus-induced membrane-bound replication complexes in the host cytoplasm. Here we show that a significant proportion (20%) of the total RNA-dependent RNA polymerase (RdRp) activity from cells infected with West Nile virus, Japanese encephalitis virus (JEV), and dengue virus is resident within the nucleus. Consistent with this, the...

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Identifiers

PMID: 16699025
DOI: 10.1128/jvi.01982-05

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