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The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype.

Diabetologia - 1 Sept 2006

Stene L C, Thorsby P M, Berg J P, Rønningen K S, Undlien D E, Joner G

Abstract excerpt

AIMS/HYPOTHESIS: Associations have been described between higher birthweight and increased risk of type 1 diabetes, and of insulin (INS) and human leucocyte antigen (HLA) genotypes that protect against diabetes with larger size at birth. We studied simultaneously the effects of size at birth, INS and HLA genotypes on the risk of type 1 diabetes to test whether the relation between size at birth and risk of type 1...

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Identifiers

PMID: 16691379
DOI: 10.1007/s00125-006-0292-6

Genes

INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype.PMID 16691379Read ↗

Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.Semantic proximity Read ↗

Type 2 diabetes risk alleles are associated with reduced size at birth.Semantic proximity Read ↗

Exposure to Gestational Diabetes Is a Stronger Predictor of Dysmetabolic Traits in Children Than Size at BirthSemantic proximity Read ↗

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Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.Semantic proximity Read ↗

Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain.Semantic proximity Read ↗

Diabetes-associated HLA-DQ genes and birth weight.Semantic proximity Read ↗

HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.Semantic proximity Read ↗

Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects.Semantic proximity Read ↗

Birth weight in newborn infants with different diabetes-associated HLA genotypes in three neighbouring countries: Finland, Estonia and Russian Karelia.Semantic proximity Read ↗

Association between small for gestational age and paternally inherited 5' insulin haplotypes.Semantic proximity Read ↗

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