Article
In vitro sensitivity to platinum-derived drugs is associated with expression of thymidylate synthase and dihydropyrimidine dehydrogenase in human lung cancer.
Oncology reports - 1 Jun 2006
Takizawa Masaya, Kawakami Kazuyuki, Obata Tohru, Matsumoto Isao, Ohta Yasuhiko, Oda Makoto, Sasaki Takuma, Watanabe Go
Abstract excerpt
Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are critical enzymes in nucleic acid metabolism. Proliferating cell nuclear antigen (PCNA) is a specific protein that is correlated with proliferative activity of cells. The TS gene has a variable number of tandem repeats (VNTR) in its 5'-untranslated region and a single nucleotide polymorphism (SNP) in the VNTR area. We examined the association...
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